Structural Biology

Unlock the world of Structural Biology through “Structural Biology” by Fouad Sabry, a comprehensive resource in the “Molecular Biophysics” series. This book explores the cuttingedge techniques and discoveries that define modern structural biology. It is an essential guide for professionals, students, and enthusiasts eager to understand the molecular underpinnings of life, offering a perfect balance between theory and application.

Chapters Brief Overview:

1: Structural biology: Introduction to the field of structural biology and its fundamental role in understanding biomolecular structures.

2: Crystallography: Overview of crystallography as a pivotal technique for studying molecular structures.

3: Xray crystallography: Exploration of Xray crystallography, its history, and significance in determining protein structures.

4: Protein Data Bank: Discussion of the Protein Data Bank, a critical resource for accessing structural data of proteins.

5: John Kendrew: A look at John Kendrew’s pioneering work in Xray crystallography, advancing the understanding of protein structure.

6: Electron crystallography: Delving into electron crystallography and its contributions to structural biology.

7: Transmission electron cryomicroscopy: The technique of transmission electron cryomicroscopy, transforming molecular imaging and structural analysis.

8: Cryogenic electron tomography: Insight into cryogenic electron tomography and its role in highresolution 3D imaging of biological specimens.

9: Michael Rossmann: Michael Rossmann’s groundbreaking research in viral structures, contributing to the evolution of structural biology.

10: Richard Henderson (biologist): Richard Henderson’s contributions to cryoEM, earning him a Nobel Prize for advancing biological imaging.

11: Molecular biophysics: Understanding the interdisciplinary relationship between molecular biology and biophysics in structural studies.

12: Resolution (structural biology): Exploring the concept of resolution in structural biology and its importance in obtaining accurate molecular models.

13: Protein crystallization: The critical process of protein crystallization, essential for successful Xray crystallography experiments.

14: Macromolecular assembly: Examination of macromolecular assembly and its impact on the functional properties of biological macromolecules.

15: Structure validation: The process of validating molecular structures to ensure accuracy and reliability in scientific findings.

16: Structural chemistry: Insights into structural chemistry and its influence on understanding the chemical properties of biomolecules.

17: Cryogenic electron microscopy: Further exploration of cryogenic electron microscopy and its role in structural analysis of macromolecules.

18: Tamir Gonen: Investigating the contributions of Tamir Gonen in advancing cryoEM techniques for structural studies.

19: Microcrystal electron diffraction: An exploration of microcrystal electron diffraction and its potential for studying small protein crystals.

20: Timeline of crystallography: A historical timeline outlining the key milestones in the development of crystallography as a technique.

21: Crystal: A detailed discussion on the role of crystals in structural biology, serving as a foundation for many analytical techniques.

The book weaves together the latest advancements, offering students, researchers, and professionals a clear understanding of how molecular structures dictate biological function. By covering topics from crystallography to molecular biophysics, this work not only educates but also invites new ideas in molecular research.