Lifespan
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Kesan
- Olga Gmembagikan kesantahun lalu
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Kutipan
- Leenamembuat kutipan5 tahun yang lalu
Once you recognize that there are universal regulators of aging in everything from yeast to roundworms to mice to humans . . .
. . . and once you understand that those regulators can be changed with a molecule such as NMN or a few hours of vigorous exercise or a few less meals . . .
. . . and once you realize that it’s all just one disease . . .
. . . it all becomes clear - aurelia anastasiamembuat kutipan2 tahun yang lalu
stem cells. Yet the ICE mice were suffering from a loss of body mass, mitochondria, and muscle strength and an increase in cataracts, arthritis, dementia, bone loss, and frailty.
All of the symptoms of aging—the conditions that push mice, like humans, farther toward the precipice of death—were being caused not by mutation but by the epigenetic changes that come as a result of DNA damage signals.
We hadn’t given the mice all of those ailments. We had given them aging.
And if you can give something, you can take it away. - aurelia anastasiamembuat kutipan2 tahun yang laluHere’s the vital takeaway: we could age mice without affecting any of the most commonly assumed causes of aging. We hadn’t made their cells mutate. We hadn’t touched their telomeres. We hadn’t messed with their mitochondria.
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